Tcell subset described as CD 4 loCD 40 + Tcells ( TCD 40 ) in human type 1 diabetes
نویسندگان
چکیده
a The Webb-Waring Institute, University of Colorado at Denver and Health Sciences Center, 4200 East 9th Ave, Denver, CO, USA b The Barbara Davis Childhood Diabetes Center, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA c UCSF Diabetes Center, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA, USA d TheDepartmentofMedicine,University of ColoradoDenver andHealth Sciences Center, 4200 East 9thAveDenver, CO80262, USA e Medicine and Research Services, Denver VA Medical Center, 1055 Clermont St., Denver, CO 80220, USA
منابع مشابه
Pathogenesis of type 1 diabetes: genetics
There has been much progress in the identification of genes and molecular pathways involved in the pathogenesis of type 1 diabetes. Human histocompatibility (HLA) complex genes are the most powerful susceptibility determinants. The stronger effect is from alleles coding for selected HLA class I and class II antigen-presenting molecules, which are restricting elements for autoreactive CD8 and CD...
متن کاملAblation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice
Clinical complications of atherosclerosis are almost exclusively linked to destabilization of the atherosclerotic plaque. Batf3-dependent dendritic cells specialize in cross-presentation of necrotic tissue-derived epitopes to directly activate cytolytic CD8 Tcells. The mature plaque (necrotic, containing dendritic cells and CD8 Tcells) could offer the ideal environment for cross-presentation, r...
متن کاملHigh rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial Doppler monitoring.
BACKGROUND AND PURPOSE Clot dissolution with tissue plasminogen activator (tPA) can lead to early clinical recovery after stroke. Transcranial Doppler (TCD) with low MHz frequency can determine arterial occlusion and monitor recanalization and may potentiate thrombolysis. METHODS Stroke patients receiving intravenous tPA were monitored during infusion with portable TCD (Multigon 500M; DWL Mul...
متن کاملHCV persistence and immune evasion in the absence of memory T cell help.
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ Tcells are essential for this protection. Antibody-mediated depletion of CD4+ Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic m...
متن کاملYKL-40 - an emerging biomarker in cardiovascular disease and diabetes
Several inflammatory cytokines are involved in vascular inflammation resulting in endothelial dysfunction which is the earliest event in the atherosclerotic process leading to manifest cardiovascular disease. YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction by promoting chemotaxis, cell attachment and migration, reorganization and tissue remodelling as a response to en...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007